Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90

In radiobiology circulating T-lymphocytes are used as “natural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to accumulated dose. addition, stable (translocations) detected years and decades exposure. Estimation doses lymphocytes requires consideration two dose components: by lymphocyte precursors (progenitors) red bone marrow; lymphoid organs/tissues during circulation. A recently created model T-lymphocyte takes into account all these components, well age-dependent dynamics T-lymphocytes. The use a approach especially important assessing from osteotropic beta emitters ( 89,90 Sr). They accumulate locally expose predominately marrow. other organs tissues much lower. objective this study evaluate conversion factors ingested Sr cumulative their progenitors (DC L ). For calculations, previously developed new coefficients for marrow, estimated on basis sex-and-age-dependent biokinetic dosimetric human skeleton were used. As result, DCL values evaluated first time. age at time intake varied newborn 35 years, examination (blood sampling age) was up 75 years. maximum DC both 90 89 typical children life. It has been shown radionuclides lower than those but significantly higher tissues. effect sex manifested 10 older. area application covers population radioactively contaminated territories (the Urals region, zone Chernobyl accident), personnel nuclear industry enterprises.